Publications

Selected publications


Emma E Kim, Seunghoon Lee, Cue Hyunkyu Lee, Hyunjung Oh, Kyuyoung Song, Buhm Han¶. “FOLD: A method to optimize power in meta-analysis of genetic association studies with overlapping subjects.” Bioinformatics. (Online published: btx463). 2017.

Cue Hyunkyu Lee, Eleazar Eskin, Buhm Han¶. “Increasing the power of meta-analysis of genome-wide association studies to detect heterogeneous effects.” Bioinformatics. (ISMB2017) 33(14):i379-i388. 2017.

Dat Duong, Jennifer Zou, Farhad Hormozdiari, Jae hoon Sul, Jason Ernst, Buhm Han¶, Eleazar Eskin¶. “Using genomic annotations increases statistical power to detect eGenes.” Bioinformatics. (ISMB2016) 32(12):i156-i163. 2016.

Power of BUHMBOX as a function of effect size. Buhm Han¶*, Jennie G Pouget*, Kamil Slowikowski, Eli Stahl, Cue Hyunkyu Lee, Dorothee Diogo, Xinli Hu, Yu Rang Park, Eunji Kim, Peter K Gregersen, Solbritt Rantapää Dahlqvist, Jane Worthington, Javier Martin, Steve Eyre, Lars Klareskog, Tom Huizinga, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Naomi R Wray, Soumya Raychaudhuri¶. “A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.” Nature Genetics. 48(7):803-10. 2016. 
The Pairwise Correlation between Each Phenotype Pair in the NFBC Dataset
Farhad Hormozdiari, Eun Yong Kang, Michael Bilow, Eyal Ben-David, Chris Vulpe, Stela McLachlan, Aldons J. Lusis, Buhm Han¶, Eleazar Eskin¶. “Imputing phenotypes for genome-wide association studies.” The American Journal of Human Genetics. 99(1):89-103. 2016.

https://static-content.springer.com/image/art%3A10.1186%2Fs13059-016-0903-6/MediaObjects/13059_2016_903_Fig1_HTML.gif Jong Wha J. Joo, Farhad Hormozdiari, Buhm Han¶, and Eleazar Eskin¶. “Multiple testing correction in linear mixed models.” Genome Biology. 17(1):62, 2016.

Buhm Han¶, Dat Duong, Jae Hoon Sul, Paul I. W. de Bakker, Eleazar Eskin, and Soumya Raychaudhuri. “A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.” Human Molecular Genetics. 25(9):1857-66. 2016.
 
 
 Jae Hoon Sul, Towfique Raj, Simone de Jong, Paul IW de Bakker, Soumya Raychaudhuri, Roel A Ophoff, Barbara E Stranger, Eleazar Eskin, Buhm Han¶. "Accurate and Fast Multiple-Testing Correction in eQTL Studies." The American Journal of Human Genetics. 96(6):857-868. 2015.
¶ : Corresponding author.
 
 
 Yukinori Okada*, Buhm Han*, Lam C. Tsoi, Philip E. Stuart, Eva Ellinghaus, Trilokraj Tejasvi, Vinod Chandran, Fawnda Pellett, Remy Pollock, Anne M. Bowcock, Gerald G. Krueger, Michael Weichenthal, John J. Voorhees, Proton Rahman, Peter K. Gregersen, Andre Franke, Rajan P. Nair, Goncalo R. Abecasis, Dafna D. Gladman, James T. Elder, Paul I.W. de Bakker, and Soumya Raychaudhuri. “Fine-mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.” The American Journal of Human Genetics. 95(2):162-172. 2014.
* : Equal contribution.
 
 
 Buhm Han, Dorothee Diogo, Steve Eyre, Henrik Kallberg, Alexandra Zhernakova, John Bowes, Leonid Padyukov, Yukinori Okada, Miguel A. Gonzalez-Gay, Solbritt Rantapaa-Dahlqvist, Javier Martin, Tom W J Huzinga, Robert Plenge, Jane Worthington, Peter K. Gregersen, Lars Klareskog, Paul I. W. de Bakker, Soumya Raychaudhuri. "Fine-mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity." The American Journal of Human Genetics. 94(4):522-523. 2014. (Selected as F1000 recommendation)
 
 
 Buhm Han*, Eun Yong Kang*, Soumya Raychaudhuri, Paul I. W. de Bakker, Eleazar Eskin. "Fast Pairwise IBD Association Testing in Genome-wide Association Studies." Bioinformatics. 30(2):206-13. 2014.
* : Equal contribution.
 
 
 Eun Yong Kang*, Buhm Han*, Nicholas Furlotte*, Jong Wha Joo, Diana Shih, Richard Davis, Aldons J. Lusis, Eleazar Eskin. "Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice." PLOS Genetics. 10(1): e1004022. 2013.
* : Equal contribution.
 
 
 Jae Hoon Sul*, Buhm Han*, Chun Ye*, Ted Choi, Eleazar Eskin. "Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches." PLoS Genetics. 9(6): e1003491. 2013.
* : Equal contribution.
 
 
 Xiaoming Jia*, Buhm Han*, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick J. Concannon, Stephen S. Rich, Soumya Raychaudhuri, Paul I.W. de Bakker. "Imputing Amino Acid Polymorphisms in Human Leukocyte Antigenes." PLoS One. 8(6):e64683. 2013.
* : Equal contribution.
 
 
 Buhm Han, Eleazar Eskin. "Interpreting Meta-Analysis of Genome-Wide Association Studies." PLoS Genetics. 8(3):e1002555, 2012.
 
 
 Buhm Han, Eleazar Eskin. "Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies." The American Journal of Human Genetics. 88(5):586-598, 2011.
 
 
 Buhm Han, Hyun Min Kang, Eleazar Eskin. "Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers." PLoS Genetics. 5:4,e1000456, 2009.



Full publication list

Peer-reviewed International Journal publications (SCI/SCIE)

¶ : Correspondng author.

* : Equal contribution. 

Purple color: First author.

Blue color: Corresponding author.

    2017
  1. Emma E Kim, Seunghoon Lee, Cue Hyunkyu Lee, Hyunjung Oh, Kyuyoung Song, Buhm Han¶. “FOLD: A method to optimize power in meta-analysis of genetic association studies with overlapping subjects.” Bioinformatics. (Online published: btx463). 2017.

  2. Cue Hyunkyu Lee, Eleazar Eskin, Buhm Han¶. “Increasing the power of meta-analysis of genome-wide association studies to detect heterogeneous effects.” Bioinformatics. 33(14):i379-i388. 2017.

  3. Dat Duong¶, Lisa Gai, Sagi Snir, Eun Yong Kang, Buhm Han, Jae Hoon Sul, Eleazar Eskin¶. “Applying meta-analysis to genotype-tissue expression data from multiple tissues to identify eQTLs and increase the number of eGenes.” Bioinformatics. 33(14):i67-i74. 2017.

  4. Ho-Su Lee, Hyunjung Oh, Suk-Kyun Yang, Jiwon Baek, Seulgi Jung, Myunghee Hong, Kyung Mo Kim, Hyoung Doo Shin, Kyung-Jo Kim, Sang Hyoung Park, Byong Duk Ye, Buhm Han, Kyuyoung Song¶. “X chromosome-wide association study identifies a susceptibility locus for inflammatory bowel disease in Koreans.” Journal of Crohn's and Colitis. 11(7):820-830. 2017.

  5. 2016
  6. Suk-Kyun Yang, Myunghee Hong, Hyunjung Oh, Hui-Qi Low, Seulgi Jung, Seonjoo Ahn, Youngjin Kim, Jiwon Baek, Cue Hyunkyu Lee, Eunji Kim, Kyung Mo Kim, Byong Duk Ye, Kyung-Jo Kim, Sang Hyoung Park, Ho-Su Lee, Inchul Lee, Hyoung Doo Shin, Buhm Han, Dermot PB McGovern, Jianjun Liu, Kyuyoung Song¶. “Identification of loci at 1q21 and 16q23 that affect susceptibility to inflammatory bowel disease in Koreans.” Gastroenterology. 151(6):1096-1099. e4. 2016.

  7. Eun Yong Kang, Lisa J Martin, Serghei Mangul, Warin Isvilanonda, Jennifer Zou, Eyal Ben-David, Buhm Han, Aldons J Lusis, Sagiv Shifman, Eleazar Eskin¶. “Discovering single nucleotide polymorphisms regulating human Gene expression using allele specific expression from RNA-seq data.” Genetics. 204(3):1057-1064. 2016.

  8. Jaeyun Jung*, Cue Hyunkyu Lee*, Hyang Sook Seol, Yeon Sook Choi, Eunji Kim, Eun Ji Lee, Je-Keun Rhee, Shree Ram Singh, Eun Sung Jun, Buhm Han, Seung Mo Hong, Song Cheol Kim¶, Suhwan Chang¶. “Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature.” Oncotarget. 7(38):62533-63546. 2016.

  9. Eun Yong Kang, Yurang Park, Xiao Li, Ayellet V. Segre, Buhm Han¶, and Eleazar Eskin¶. “ForestPMPlot: a flexible tool for visualizing heterogeneity between studies in meta-analysis.” G3. 6(7):1793-8. 2016.

  10. Farhad Hormozdiari, Eun Yong Kang, Michael Bilow, Eyal Ben-David, Chris Vulpe, Stela McLachlan, Aldons J. Lusis, Buhm Han¶, Eleazar Eskin¶. “Imputing phenotypes for genome-wide association studies.” The American Journal of Human Genetics. 99(1):89-103. 2016.

  11. Buhm Han¶*, Jennie G Pouget*, Kamil Slowikowski, Eli Stahl, Cue Hyunkyu Lee, Dorothee Diogo, Xinli Hu, Yu Rang Park, Eunji Kim, Peter K Gregersen, Solbritt Rantapää Dahlqvist, Jane Worthington, Javier Martin, Steve Eyre, Lars Klareskog, Tom Huizinga, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Naomi R Wray, Soumya Raychaudhuri¶. “A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.” Nature Genetics. 48(7):803-10. 2016. 

  12. Buhm Han¶, Dat Duong, Jae Hoon Sul, Paul I. W. de Bakker, Eleazar Eskin, and Soumya Raychaudhuri. “A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.” Human Molecular Genetics. 25(9):1857-66. 2016.

  13. Femke N.G. van ’t Hof, Ynte M. Ruigrok, Cue Hyunkyu Lee, Stephan Ripke, Graig Anderson, Mariza de Andrade, Annette F. Baas, Jan D. Blankensteijn, Erwin P. Böttinger, Matthew J. Bown, Joseph Broderick, Philippe Bijlenga, David S. Carrell, Dana C. Crawford, David R. Crosslin, Christian Ebeling, Johan G Eriksson, Myriam Fornage, Tatiana Foroud, Mikael von und zu Fraunberg, Christoph M. Friedrich, Emília I. Gaál, Omri Gottesman, Dong-chuan Guo, Seamus C Harrison FRCS, Juha Hernesniemi, Albert Hofman, Ituro Inoue, Juha E. Jääskeläinen, Gregory T. Jones, Lambertus A.L.M. Kiemeney, Riku Kivisaari, Nerissa Ko, Seppo Koskinen, Michiaki Kubo, Iftikhar J. Kullo, Helena Kuivaniemi, Mitja I. Kurki, Aki Laakso, Dongbing Lai, Suzanne M. Leal, Hanna Lehto, Scott A. LeMaire, Siew-Kee Low, Jennifer Malinowski MS, Catherine A. McCarty, Dianna M. Milewicz, Thomas H. Mosley, Yusuke Nakamura, Hirofumi Nakaoka, Mika Niemelä, Jennifer Pacheco, BA, Peggy L. Peissig, Joanna Pera, Laura Rasmussen-Torvik, Marylyn D. Ritchie, Fernando Rivadeneira, Andre M. van Rij, Regie Lyn P. Santos-Cortez, Athanasios Saratzis, Agnieszka Slowik, Atsushi Takahashi, Gerard Tromp, André G. Uitterlinden, Shefali S. Verma, Sita H. Vermeulen, Gao T. Wang, Aneurysm Consortium, Vascular Research Consortium of New Zealand, Buhm Han, Gabriël J.E. Rinkel FRCP(E), Paul I.W. de Bakker. “Shared genetic risk factors of intracranial, abdominal and thoracic aneurysms.” Journal of the American Heart Association. 5(7):e002603. 2016.

  14. Dat Duong, Jennifer Zou, Farhad Hormozdiari, Jae hoon Sul, Jason Ernst, Buhm Han, Eleazar Eskin. “Using genomic annotations increases statistical power to detect eGenes.” Bioinformatics. (ISMB2016) 32(12):i156-i163. 2016.

  15. Bram P. Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E. Stuart, Javier Guterriez Achury, Vanisha Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D. Mayes, Evangelos Evangelou, Rajan P Nair, Struan F.A. G Grant, Constantin Polychronakos, Timothy R.D. Radstake, David A. van Heel, Melanie L Dunstan, Nicholas W. Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S. Markus, James T. Elder, Jo Knight, Dan E. Arking, Timothy D. Spector, Bobby P.C. Koeleman, Cornelia P. van Duijn, Javier Martin, Andrew P. Morris, Rinse K. Weersma, Cisca Wijmenga, Patricia Munroe, John R.B. Perry, Jennie G. Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z. Alizadeh, PAGE Consortium, International Stroke Genetics Consortium, Systematic Sclerosis Consortium, Treat OA Consortium Consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS Consortium, International Parkinson's Disease Genomics Consortium, Autism Working Group of the Psychiatric Genomics Consortium, CKDGen Consortium, the GERAD1 Consortium, ICBP Consortium, Inflammation Working Group of the CHARGE Consortium. “Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: A large scale cross-consortia Mendelian randomization study.” PLOS Medicine. 13(6): e1001976. 2016.

  16. Jong Wha J. Joo, Farhad Hormozdiari, Buhm Han¶, and Eleazar Eskin¶. “Multiple testing correction in linear mixed models.” Genome Biology. 17(1):62, 2016.

  17. David Ellinghaus, Luke Jostins, Sarah L Spain, Adrian Cortes, Jörn Bethune, Buhm Han, Yu Rang Park, Soumya Raychaudhuri, Matthias Hübenthal, Trine Folseraas, Yunpeng Wang, Tonu Esko, Andres Metspalu, Harm-Jan Westra, Lude Franke, Tune Pers, Rinse Weersma, Collij Valerie, Mauro D’Amato, Jonas Halfvarson, Wolfgang Lieb, Franziska Degenhardt, Andreas J Forstner, Andrea Hofmann, The International IBD Genetics Consortium (IIBDGC), International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Collaborative Association Study of Psoriasis (CASP), Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium, Stefan Schreiber, Ulrich Mrowietz, Brian D Juran, Konstantinos N Lazaridis, Anders M Dale, Richard C Trembath, Stephan Weidinger, Michael Weichenthal, Eva Ellinghaus, James T Elder, Jonathan NWN Barker, Ole A Andreassen, Dermot P McGovern, Tom H Karlsen, Jeffrey C Barrett, Miles Parkes, Matthew A Brown, Andre Franke. “Combined analysis of five chronic inflammatory diseases reveals 27 new associations and highlights disease-specific patterns at shared loci.” Nature Genetics. 48:510-518, 2016.

  18. NINDS Stroke Genetics Network (SiGN), International Stroke Genetics Consortium (ISGC). "Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study." Lancet Neurology. 15(2):174-184, 2016.

    2015
  19. Michael J Ombrello, Elaine F Remmers, Ioanna Tachmazidou, Alexei Grom, Dirk Foell, Johannes-Peter Haas, Alberto Martini, Marco Gattorno, Seza O ̈zen, Sampath Prahalad, Andrew S Zeft, John F Bohn- sack, Elizabeth D Mellins, Norman T Ilowite, Ricardo Russo, Claudio Len, Maria Odete E Hilario, Sheila Oliveira, Rae S M Yeung, Alan Rosenberg, Lucy R Wedderburn, Jordi Anton, Tobias Schwarz, Anne Hinks, Yelda Bilginer, Jane Park, Joanna Cobb, Colleen L Satorius, Buhm Han, Elizabeth Baskin, Sara Signa, Richard H Duerr, J P Achkar, M Ilyas Kamboh, Kenneth M Kaufman, Leah C Kottyan, Dalila Pinto, Stephen W Scherer, Marta E Alarc ́on-Riquelme, Elisa Docampo, Xavier Estivill, Ahmet Gu ̈l, British Society of Pediatric, Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAP- PORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group, Paul I W de Bakker, Soumya Ray- chaudhuri, Carl D Langefeld, Susan Thompson, Eleftheria Zeggini, Wendy Thomson, Daniel L Kastner, Patricia Woo, the International Childhood Arthritis Genetics (INCHARGE) Consortium. "HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis." Proceedings of the National Academy of Sciences, 112(52):15970–15975, 2015.

  20. Tobias L Lenz, Aaron J Deutsch, Buhm Han, Xinli Hu, Yukinori Okada, Stephen Eyre, Michael Knapp, Alexandra Zhernakova, Tom WJ Huizinga, Gonçalo Abecasis, Jessica Becker, Guy E Boeckxstaens, Wei-Min Chen, Andre Franke, Dafna D Gladman, Ines Gockel, Javier Gutierrez-Achury, Javier Martin, Rajan P Nair, Markus M Nöthen, Suna Onengut-Gumuscu, Proton Rahman, Solbritt Rantapää-Dahlqvist, Philip E Stuart, Lam C Tsoi, David A van Heel, Jane Worthington, Mira M Wouters, Lars Klareskog, James T Elder, Peter K Gregersen, Johannes Schumacher, Stephen S Rich, Cisca Wijmenga, Shamil R Sunyaev, Paul IW de Bakker, Soumya Raychaudhuri. "Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases." Nature Genetics47(9):1085-1090. 2015. 

  21. Xinli Hu, Aaron J Deutsch, Tobias L Lenz, Suna Onengut-Gumuscu, Buhm Han, Wei-Min Chen, Joanna MM Howson, John A Todd, Paul IW de Bakker, Stephen S Rich, Soumya Raychaudhuri. "Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk." Nature Genetics. 47(8):898-905. 2015.

  22. Gosia Trynka, Harm-Jan Westra, Kamil Slowikowski, Xinli Hu, Han Xu, Barbara E Stranger, Buhm Han, Soumya Raychaudhuri. "Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci." The American Journal of Human Genetics. 97(1):139-152. 2015.

  23. Jae Hoon Sul, Towfique Raj, Simone de Jong, Paul IW de Bakker, Soumya Raychaudhuri, Roel A Ophoff, Barbara E Stranger, Eleazar Eskin, Buhm Han. "Accurate and Fast Multiple-Testing Correction in eQTL Studies." The American Journal of Human Genetics. 96(6):857-868. 2015.

  24. Sebastien Viatte, Darren Plant, Buhm Han, Bo Fu, Annie Yarwood, Wendy Thomson, Deborah PM Symmons, Jane Worthington, Adam Young, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, Soumya Raychaudhuri, Anne Barton. "Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response." JAMA. 313(16):1645-1656. 2015.

  25. Annie Yarwood, Buhm Han, Soumya Raychaudhuri, John Bowes, Mark Lunt, Dimitrios A Pappas, Joel Kremer, Jeffrey D Greenberg, Robert Plenge, Rheumatoid Arthritis Consortium International (RACI), Jane Worthington, Anne Barton, Steve Eyre. "A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk." Annals of Rheumatic Diseases. 74(1):170-6. 2015.

    2014
  26. Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Yukinori Okada, Buhm Han, Woei-Yuh Saw, Yik-Ying Teo, Sang-Cheol Bae. "The HLA-DRβ1 Amino Acid Positions 11-13-26 Explain the Majority of SLE-MHC Associations." Nature Communications. 5:5902. 2014

  27. Sarah J. Dunstan, Nguyen Thi Hue, Buhm Han, Zheng Li, Trinh Thi Bich Tram, Kar Seng Sim, Christopher M. Parry, Nguyen Tran Chinh, Ha Vinh, Nga Tran Vu Thieu, Phat Voong Vinh, Samir Koirala, Sabina Dongol, Amit Arjyal, Abhilasha Karkey, Olita Shilpakar, Christiane Dolecek, Jia Nee Foo, Le Thi Phuong, Mai Ngoc Lanh, Tan Do, Tin Aung, Do Nu Hon, Yik Ying Teo, Martin L Hibberd, Katherine L. Anders, Yukinori Okada, Soumya Raychaudhuri, Cameron P. Simmons, Stephen Baker, Paul I.W. de Bakker, Buddha Basnyat, Tran Tinh Hien, Jeremy J. Farrar, Chiea Chuen Khor. “Variation at HLA-DRB1 is associated with resistance to enteric fever.” Nature Genetics. 46(12):1333-6, 2014

  28. Yukinori Okada, Kwangwoo Kim, Buhm Han, Nisha E Pillai, Rick T-HOng, Woei-Yuh Saw, Ma Luo, Lei Jiang, Jian Yin, So-Young Bang, Hye-Soon Lee, Matthew A Brown, Sang-Cheol Bae, Huji Xu, Yik-Ying Teo, Paul IW De Bakker, Soumya Raychaudhuri. “Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.” Human Molecular Genetics. 23(25):6916-26, 2014

  29. Yukinori Okada*, Buhm Han*, Lam C. Tsoi, Philip E. Stuart, Eva Ellinghaus, Trilokraj Tejasvi, Vinod Chandran, Fawnda Pellett, Remy Pollock, Anne M. Bowcock, Gerald G. Krueger, Michael Weichenthal, John J. Voorhees, Proton Rahman, Peter K. Gregersen, Andre Franke, Rajan P. Nair, Goncalo R. Abecasis, Dafna D. Gladman, James T. Elder, Paul I.W. de Bakker, and Soumya Raychaudhuri. “Fine-mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.” The American Journal of Human Genetics. 95(2):162-172. 2014.

  30. Jong Wha J Joo,Jae Hoon Sul, Buhm Han, Chun Ye, Eleazar Eskin. "Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies." Genome Biology. 15(4):R61. 2014.

  31. Buhm Han, Dorothee Diogo, Steve Eyre, Henrik Kallberg, Alexandra Zhernakova, John Bowes, Leonid Padyukov, Yukinori Okada, Miguel A. Gonzalez-Gay, Solbritt Rantapaa-Dahlqvist, Javier Martin, Tom W J Huzinga, Robert Plenge, Jane Worthington, Peter K. Gregersen, Lars Klareskog, Paul I. W. de Bakker, Soumya Raychaudhuri. "Fine-mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity." The American Journal of Human Genetics. 94(4):522-523. 2014.

  32. Buhm Han*, Eun Yong Kang*, Soumya Raychaudhuri, Paul I. W. de Bakker, Eleazar Eskin. "Fast Pairwise IBD Association Testing in Genome-wide Association Studies." Bioinformatics. 30(2):206-13. 2014.

  33. Eun Yong Kang*, Buhm Han*, Nicholas Furlotte*, Jong Wha Joo, Diana Shih, Richard Davis, Aldons J. Lusis, Eleazar Eskin. "Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice." PLOS Genetics. 10(1): e1004022. 2013.

  34. 2013

  35. Xinli Hu, Hyun Kim, Patrick J. Brennan, Buhm Han, Clare Baecher-Allan, Philip De Jager, Michael B. Brenner, Soumya Raychaudhuri. "Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells." Proceedings of the National Academy of Sciences. 110(47):19030-5. 2013.

  36. Dan He, Zhanyong Wang, Buhm Han, Laxmi Parida, Eleazar Eskin. "IPED: Inheritance Path Based Pedigree Reconstruction Algorithm Using Genotype Data." Journal of Computarional Biology. 20(10):780-91. 2013.

  37. Jae Hoon Sul*, Buhm Han*, Chun Ye*, Ted Choi, Eleazar Eskin. "Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches." PLoS Genetics. 9(6): e1003491. 2013.

  38. Xiaoming Jia*, Buhm Han*, Suna Onengut-Gumuscu, Wei-Min Chen, Patrick J. Concannon, Stephen S. Rich, Soumya Raychaudhuri, Paul I.W. de Bakker. "Imputing Amino Acid Polymorphisms in Human Leukocyte Antigenes." PLoS One. 8(6):e64683. 2013.

  39. Oron Navon, Jae Hoon Sul, Buhm Han, Lucia Conde, Paige Bracci, Jacques Riby, Christine Skibola, Eleazar Eskin, Eran Halperin. "Rare Variant Association Testing under Low-Coverage Sequencing." Genetics. 194(3):769-79. 2013.

  40. Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A; for the North American Brain Expression Consortium, Hardy J; for the UK Human Brain Expression Database, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL. "Genome-wide association study of Tourettes syndrome." Molecular Psychiatry. 18(6):721-8. 2013.

  41. Dan He, Buhm Han, Eleazar Eskin. "Hap-seq: An Optimal Algorithm for Haplotype Phasing with Imputation using Sequencing." Journal of computational biology. 20(2):80-92. 2013.

  42. Gosia Trynka, Cynthia Sandor, Buhm Han, Han Xu, Barbara E Stranger, X Shirley Liu, Soumya Raychaudhuri. "Chromatin marks identify critical cell types for fine mapping complex trait variants." Nature Genetics. 45(2):124-30. 2013.

  43. 2012
  44. Gregory Darnell, Dat Duong, Buhm Han, Eleazar Eskin. "Incorporating Prior Information Into Association Studies." Bioinformatics. 28 (12): i147-i153, 2012. also in Proceedings of the Twentieth Annual Conference on Intelligent Systems for Molecular Biology (ISMB-2012).

  45. Buhm Han, Eleazar Eskin. "Interpreting Meta-Analysis of Genome-Wide Association Studies." PLoS Genetics. 8(3):e1002555, 2012.

  46. 2011
  47. Jae Hoon Sul, Buhm Han, Eleazar Eskin. "Increasing Power of Groupwise Association Test with Likelihood Ratio Test." Journal of Computational Biology. 18(11):1611-1624, 2011.

  48. Buhm Han, Eleazar Eskin. "Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies." The American Journal of Human Genetics. 88(5):586-598, 2011.

  49. Jae Hoon Sul, Buhm Han, Dan He, Eleazar Eskin. "An Optimal Weighted Aggregated Association Test for Identification of Rare Variants Involved in Common Diseases." Genetics. 188(1):181-8, 2011.

  50. Buhm Han, Brian Hackel, Eleazar Eskin. "Postassociation Cleaning Using Linkage Disequilibrium Information." Genetic Epidemiology. 35(1):1-10, 2011.

  51. ~2010
  52. Andrew Kirby, Hyun Min Kang, Claire M. Wade, Chris Cotsapas, Emrah Kostem, Buhm Han, Nick Furlotte, Eun Yong Kang, Manuel Rivas, Molly A. Bogue, Kelly A. Frazer, Frank M. Johnson, Erica J. Beilharz, David R. Cox, Eleazar Eskin, Mark J. Daly. "Fine Mapping in 94 Inbred Mouse Strains Using a High-Density Haplotype Resource." Genetics. 185(3):1081-1095, 2010.

  53. Buhm Han, Hyun Min Kang, Eleazar Eskin. "Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers." PLoS Genetics. 5:4,e1000456, 2009.

  54. Buhm Han*, Banu Dost*, Vineet Bafna, Shaojie Zhang. "Structural Alignment of Pseudoknotted RNA." Journal of Computational Biology. 15(5):489-504, 2008.

  55. Buhm Han, Hyun Min Kang, Myeong Seong Seo, Noah Zaitlen, Eleazar Eskin. "Efficient Association Study Design via Power-Optimized Tag SNP Selection." Annals of Human Genetics. 72(6):834-47, 2008.

Peer-reviewed Domestic Journal publications (KCI)

  1. Comparison of Two Meta- Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores. Genomics and Informatics. 2016.

  2. Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans. Genomics and Informatics. 2015.

Peer-reviewed International conference proceedings

  1. Dan He, Zhanyong Wang, Buhm Han, Laxmi Parida, Eleazar Eskin. "IPED: Inheritance Path Based Pedigree Reconstruction Algorithm Using Genotype Data." In Proceedings of the Seventeenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2013). Beijing, China: April 7-10, 2013.

  2. Dan He, Buhm Han, Eleazar Eskin. "Hap-seq: An Optimal Algorithm for Haplotype Phasing with Imputation using Sequencing Data." In Proceedings of the Sixteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2012). Barcelona, Spain: April 21-24, 2012.

  3. Jae Hoon Sul, Buhm Han, Eleazar Eskin. "Increasing Power of Groupwise Association Test with Likelihood Ratio Test." In Proceedings of the Fifteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2011). Vancouver, Canada: March 28-31, 2011.

  4. Hyun Min Kang, Noah Zaitlen, Buhm Han, Eleazar Eskin. "An Adaptive and Memory Efficient Algorithm for Genotype Imputation." In Proceedings of the Thirteenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2009). Tucson, AZ: May 18th-21st, 2009.

  5. Arthur Choi, Noah Zaitlen, Buhm Han, Knot Pipatsrisawat, Adnan Darwiche, Eleazar Eskin. "Efficient Genome Wide Tagging by Reduction to SAT." In Proceedings of the 8th Workshop on Algorithms in Bioinformatics (WABI-2008). Universitt Karlsruhe, Germany: September 15-17, 2008.

  6. Banu Dost*, Buhm Han*, Shaojie Zhang, Vineet Bafna. "Structural Alignment of Pseudoknotted RNA." In Proceedings of the Tenth Annual Conference on Research in Computational Molecular Biology (RECOMB-2006). Venice, Italy, April 2-5, 2006.